Antibody Related Databases and SoftwareAntibody related amino acid sequencing tools, nucleotide sequencing tools, structural modeling tools, and hybridoma/cell culture databases can be found below. Speciality research databases that include monoclonal and polyclonal antibodies are also included.
Use the search box or links above - Find the antibodies you need right here.
ABG: Directory of 3D structures of antibodies - The directory, created by the Antibody Group (ABG), allows a quick access to the antibody structures compiled at the Protein Data Bank (PDB). In the directory, each PDB entry has a hyperlink to the original source to make full information recovering easy. The VH and VL sequences were aligned and are reported in the VH and VL alignments. The directory will be updated monthly.
ABG: Germline gene directories of the mouse - a directory of mouse VH and VK germline segments, part of the webpage of the Antibody Group at the Instituto de Biotecnologia, UNAM (National University of Mexico)
AbMiner - users can search for commercially available antibodies and match them with their respective genomic identifiers. A unique feature of this database is that only antibodies screened by Western blot are included, which makes the antibodies listed research friendly.
Abnum - an online tool that lets you number an antibody sequence or structure automatically using the Kabat or Chothia schemes, as well as a new improved Clothia scheme created by the authors.
Antibody Central - an antibody search portal which connects catalog antibodies and research publications to the UniProt protein information resource. The tool uses a proprietary Antibody Name Dictionary model - a collection of protein names, synonyms, and symbols recognized as antibody names which are verified through a full-text search of scientific publications in HighWire Press.
European Collection of Cell Cultures - a cell culture collection service for the research community that holds over 40000 cell lines including 450+ antibodies
HIV Molecular Immunology Database - listings of HIV specific monoclonal antibodies, maps of binding sites on HIV proteins, sequence alignments showing global variation of linear binding domains, brief descriptions of how the MAb has been used in HIV studies with Medline links, and where to obtain many of the antibodies in the database.
The Hybridoma Databank - HDB holds data on various aspects of hybridomas and their immunoreactive products. Information on a hybridoma's construction and the reactivity and non-reactivity of its secreted product is included. In addition, information on the availability of an individual hybridoma and its Mab product are included. Information in the HDB is derived from literature, catalogs and survey forms.
IMGT ®, the international ImMunoGeneTics information system ® - created in 1989 by Marie-Paule Lefranc (Université Montpellier II, CNRS), IMGT is an integrated knowledge resource specializing in immunoglobulins, T cell receptors, major histocompatibility complex, immunoglobulin superfamily , major histocompatibility complex superfamily, and related proteins of the immune system for human and other vertebrate species. IMGT consists of sequence databases (IMGT/LIGM-DB, a comprehensive database of IG and TR from human and other vertebrates, with translation for fully annotated sequences, IMGT/MHC-DB, IMGT/PRIMER-DB), a genome database (IMGT/GENE-DB), a structure database (IMGT/3Dstructure-DB), a web resource (IMGT Repertoire), and interactive tools (IMGT/V-QUEST, IMGT/JunctionAnalysis, etc...). The IMGT home page provides a common access to all Immunogenetics data.
The Kabat database - search the Kabat database of sequences of proteins of immunological interest. This site is updated frequently.
Kabatman - A great source of information for molecular biologists and crystallographers on the structure of antibodies. This site also contains the KabatMan database which allows you to search the Kabat sequence database to look for sequence features, AbCheck which lets you test your antibody sequence against the Kabat sequence database to look for unusual features, and Chothia which lets you find canonical assignments for the CDRs in your antibody sequence.
Monoclonal Antibody Index - a biotechnology database with yearly updated information on more than 9000 monoclonal antibodies produced for the diagnosis an-d therapy of cancer, transplant, infection, heart-related disorders, etc...
PIGS - Prediction of ImmunoGlobulin Structures - use this web interface to automatically model immunoglobulin variable domains based on the canonical structure method. The output is a 3D model of the target antibody that can then be downloaded or displayed online.
RosettaAntibody - a FV homology modeling server - a homology modeling server that predicts antibody Fv region structures using knowledge-based techniques for template selection, de novo loop modeling for creating CDR-H3, grafting for non-H3 CDR loops, and docking to optimize the orientation of the light and heavy chains.
SACS - (Summary of Antibody Crystal Structures) is an automatically updated summary of all antibody structures in the Protein Data Bank (PDB). New PDB files processed immediately as they arrive to determine whether they are antibodies and if so, relevant information is extracted and made available on the web.
SCOP - search "SCOP" (structural classification of proteins) for references and structural information on antibodies by keyword or sequence
STATdxPathIQ - formerly Immunoquery. STATdxPathIQ is a diagnostic decision making tool for pathology that uses current, peer-reviewed literature to suggest immunohistochemical panels for the differentiation of similarly appearing tumor types. The website also contains high quality typical and atypical histochemical and immunohistochemical images to aid researchers in differential diagnosis. STATdxPathIQ evolved from ImmunoQuery, a meta-analysis search engine for use by pathologists.
V BASE - V BASE is a comprehensive directory of all human germline variable region sequences compiled from over a thousand published sequences, including those in the current releases of the Genbank and EMBL data libraries.
WAM - Web Antibody Modelling - WAM is an online facility for generating a 3D model of an antibody Fv from its sequence. Based on Oxford Molecular's AbM, WAM uses sequence homology to build the frameworks, the most sequence-homologous member of the canonical class to construct the canonical loops, and a combination of database and conformational searches to construct the non-canonical loops. The putative models are then screened using a combination of energetic and knowledge-based approaches. Modelling is free for the first model for academic users; there is a small charge ($100) for subsequent models. See the web site for more details for commercial users.
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